Информационный ключ к памяти мозга

Abstract

Neuron reactions produced by neurotransmitters and conformation transitions of receptors are analyzed. In plasmatic membrane, receptors and integrated channels form the separate mosaics of iono- and metabotropic receptive clusters (IRC and MRC). They realize transmembrane signaling that depends on conformation mobility and separate (sub- or perisynaptic) localization of IRC and MRC. Depending on membrane potential, MRC acts as bistable (W) or monostable (R) molecular trigger allowing to write down or to read the information respectively. The conformation changes were researched under electrical and chemical stimuli. It is shown that dual action of the stimuli transfers a receptive cluster in the third conformation, where adhesion immobilizes receptors in cluster. This decreases their conformation mobility in IRC, inactivates channel conductivity, and MRC becomes an engram element. Conformation properties of MRC elucidate mechanisms of short-term and long-term memory and clarify engram stratification on age. Together with synaptic environment, the set of MRCs forms an addressed memory media, where recording and reproducing of neural pulse texts are alternated due to variability of the ERP and slow potentials and resulted space mobility of R/W modes.